Author  
Place of duty  
Title   Hodgkin 씨 병 환자에서 과량의 Vinblastine 투여후 발생한 독성 ( Serious Toxicities Induced by Vinblastine Overdose in a Patient with Relapsed Hodgkin's Disease )
Publicationinfo   1994 Jan; 026(05): 841-847.
Key_word   Vinblastine overdose, Hodgkins disease
Full-Text  
Abstract   Vinblastine, referred to as a vinka alkaloid, has been used as a component of the various chemotherapeutic regimens in the treatment of nonseminomatous testicular carcinoma, chorioearcinoma, non-small cell lung carcinoma, bladder cancer, head and neck cancer and cervical cancer. Vinblastine has been used as a main component of ABVD combination therapy for the patients with advanced Hodgkins disease who relapsed after therapy with the MOPP regimen. The major adverse effects of usual dosage of vinblatine are myelosuppression, nausea, vomiting, local effects(phlebitis, necrosis when extravasated), and peripheral and autonomic neuropathies. We experienced the life threatening toxicities including bone marrow suppression, oral mucositis, peripheral neuropathies and paralytic ileus in a 41-year-old male patient with re- lapsed Hodgkins disease who was errorneously treated with 50 mg of vinblastine. The patient was recovered completely with intensive supportive treatment.
저 자   한상국(Sang Kook Han),김용주(Yong Joo Kim),한지연(Ji Youn Han),강진형(Jin Hyoung Kang),문한림(Han Lim Moon),홍영선(Young Seon Hong),김훈교(Hoon Kyo Kim),이경식(Kyung Shik Lee),김동집(Dong Jip Kim)